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KMID : 0357919770110040309
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Korean Journal of Pathology
1977 Volume.11 No. 4 p.309 ~ p.314
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On the Ultrastructural Changes of Rat Myocardial Fiber Induced by Methoxy- flurane Anesthesia
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이동구(李東久)/Dong Koo Lee
정재명(鄭宰明)/홍석재(洪錫宰)/Jae Myung Chung/Suk Jae Hong
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Abstract
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The author studied the ultrastructural changes of the myocardial fibers under the
methoxyflurane anesthesia. Nine albino rats were anesthetized with methoxyflurane for
60 minutes. Each of three group were sacrificed immediately, four hours and twelve
hours after anesthesia respectively and then heart were extracted out.
The results obtained were summarized as follow:
First group revealed mild degenerative changes in mitochondria of myocardial fiber.
Cristae were decreased in number, and partial disruption, and fused together to form
large irregular shaped body, chondriosphere of de Robertis. Sarcoplasmic reticulum was
slightly dilated and glycogen particles were also slightly decreased. Second group re-
vealed milder change than first group. The third group revealed to the normal structure.
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